What is IGF-1 LR3? What is IGF-1 Des?

IGF-1 (Insulin-like growth factor-1) is an endocrine hormone that is produced in the liver. The production of IGF-1 is increased in the presence of growth hormone.

IGF stands for insulin-like growth factor. Insulin-like growth factor 1 (IGF-1) is a polypeptide protein hormone similar in molecular structure to insulin . It plays an important role in childhood growth and continues to have effects in adults. It is a natural substance that is produced in the human body and is at its highest natural levels during puberty. (Edited by Hongxi Pharm)

During puberty IGF is the most responsible for the natural muscle growth that occurs during these few years. There are many different things that IGF does in the human body. Among the effects the most positive are increased amino acid transport to cells, increased glucose transport, increased protein synthesis, decreased protein degradation, and increased RNA synthesis.

IGF-1 LR3 Details:

IGF-1 Benefits:

Why is this IGF-1 important for a bodybuilder or athlete? Let’s take a look at the list:

• Helps regulate fat for use as energy, resulting in fat loss.
• Contributes to anti aging. As we get older, IGF-1 production slows down and this results in cell reduction. Low levels of IGF-1 are linked to heart failure, lower brain cell regulation and neuron function. Not to mention muscle tissue breakdown.
• Helps to increase nutrient shuttling (protein synthesis).
• Increases regenerative functions of nerve tissues.
• Boosts the ability to cause hyperplasia in muscle cells resulting in fuller muscle tissue.

IGF-1 LR3 Specification:

IGF-1 LR3 and IGF-1 DES:

IGF-1 variants are split into two groups: IGF-1 LR3 and DES IGF-1 (usually presented as IGF-1 DES). Base IGF-1 has a very short half life (about 10-20 minutes); as a result, it is quickly destroyed by the body. This is why IGF-1 was modified to make the amino acid analog IGF-1 LR3 (Long). The other variant of IGF-1 called DES IGF-1 is a truncated version that is 10X more potent than IGF-1. Both variants are similar to its root but have different actions, allowing them to function in a specific ways.

IGF-1 LR3

Long arginine 3-IGF-1, abbreviated as IGF-1 LR3 or LR3-IGF-1, is a synthetic protein and lengthened analogue ofhuman insulin-like growth factor 1 (IGF-1). IGF-1 LR3 has a half-life of about 20-30 hours and is much more potent than base IGF-1. Since its half-life is about a day, the IGF-1 LR3 will circulate the body, for around 24 hours, binding to receptors and activating cell communication that improves muscle growth and fat loss.

LR3 prevents glucose from entering into cells, which, in turn, forces the body to burn fat and not sucrose. In addition, its long half-life is desirable for another reason; site injections aren’t necessary, as IGF-1 LR3 will cycle the body binding to all muscle cells for about a day.

Long R3 IGF-1 is signifacantly more potent than IGF-1. The enhanced potency is due to the decreased binding of Long R3 IGF-1 to all known IGF binding proteins. These binding proteins normally inhibit the biological actions of IGF’s.

The amino acid sequence of IGF-1 LR3 is MFPAMPLSSL FVNGPRTLCG AELVDALQFV CGDRGFYFNK PTGYGSSSRR APQTGIVDEC CFRSCDLRRL EMYCAPLKPA KSA.

IGF-1 DES

DES IGF-1 is the shorter version of the IGF-1 chain. It is five (5) times more powerful than IGF-LR3 and ten (10) times more powerful than regular base IGF-1. The half-life for DES is about 20-30 minutes, which means this is a very delicate chain. Therefore, administration should only be done at the site where you want to see muscle growth. DES has the ability to stimulate muscle hyperplasia better than LR3. In simple terms, it’s best used for site injections, rather than overall growth.

des(1-3)IGF-1 lacks the first three amino acids at the N-terminus of IGF-1 (for a total of 67 amino acids, relative to the 70 of IGF-1). As a result of this difference, it has considerably reduced binding to the insulin-like growth factor-binding proteins (IGFBPs) and enhanced potency  relative to IGF-1.

The amino acid sequence of des(1-3)IGF-1 is TLCGAELVDA LQFVCGDRGF YFNKPTGYGS SSRRAPQTGI VDECCFRSCD LRRLEMYCAP LKPAKSA.

In addition, DES is known to bind to receptors that have been deformed by lactic acid, which is often present during workouts. This allows the DES to attach itself to a mutated receptor and signal tissue growth during training. DES can be used longer and more frequently than LR3.

Quick Guide:
1. Swab the top of your sterile vial with alcohol prep pad (70% isopropyl alcohol)
2. Mix 7.5mL distilled water with 1.0mL vinegar
3. Add Whatman syringe filter
4. Add sterile ~20ga. needle to end of Whatman filter
5. Inject the 8.5mL of solution into the sterile vial
6. You now have sterile 0.6% acetic acid

Reconstituting IGF-1 LR3:

Reconstitution is simply the addition of the 0.6% AA to your lyophilized IGF-1.
Assumption: 1mg/mL IGF-1/AA (1mg IGF-1 will be combined with 1mL AA; 1mg IGF-1 is the same as 1,000mcg) (Edited by Hongxi Pharm)

1. Swab the top of your IGF-1 vial with a sterile alcohol prep pad
   2. Swab the top of your 0.6% AA vial with a sterile alcohol prep pad
   3. Using either multiple insulin syringe volumes (example: 2 x 0.5cc) or a single large syringe, obtain 1.0mL of 0.6% AA.
   4. In the IGF-1 vial, insert a sterile ~20 ga. needle to act as a vent
   5. Inject the 1.0mL of AA very slowly and dribble it down the side of the vial.
   a. Be very careful with this peptide as it is very delicate!
   6. Remove the needle & syringe and discard
   7. Gently swirl the vial or roll between your hands.
   a. Again, be very gentle here
   8. You now have 1mg/mL of IGF-1
   a. This is the same as: 1,000mcg/mL

@Hongxi Pharm Team
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