99% Hormônio sexual masculino Avanafil pó For Erectile Dysfunction
Avanafil Powder Inspection:
|Avanafil Also known as
|Avanafil CAS No
||White to Off-White Cyrstalline Solid.
|Avanafil Molecular Formula
|Avanafil Molecular Weight
|Avanafil Melting point
||treatment of erectile dysfunction. A phosphodiesterase 5 inibidor da.
||Produtos farmacêuticos, API’s. Disfunção erétil; Inhibitors
Avanafil is a PDE5 inhibitor approved for erectile dysfunction by EMA and FDA, Avanafil acts by inhibiting a specific phosphodiesterase type 5 enzyme which is found in various body tissues, while primarily in the corpus cavernosum penis, as well as the retina. Other similar drugs are vardenafil,sildenafil and tadalafil.
The advantage of avanafil is it has very fast onset of action compared with other PDE5 inhibitors, and it is absorbed quickly, reaching a maximum concentration in about 30–45 minutes. About two-thirds of the participants were able to engage in sexual activity within 15 minutos.
Avanafil acts by inhibiting a specific phosphodiesterase type 5 enzyme which is found in various body tissues, but primarily in the corpus cavernosum penis, as well as the retina.Other similar drugs are tadalafil and vardenafil. Avanafil occurs as white crystalline powder, molecular formula C23H26ClN7O3 and molecular weight of 483.95 and is slightly soluble in ethanol, praticamente insolúvel em água, and soluble in 0.1 mol/L hydrochloric acid.
Avanafil is a potent, highly selective phosphodiesterase 5 inibidor da, in vitro experiments showed that the selectivity of phosphodiesterase 5 stronger than . The compound dear compliance weak against other phosphodiesterase, and effect of adenosine receptor decreased, suggesting that the cardiovascular effects of avanafil should be weaker than .
Pre clinical study showed that avanafil and organic nitrate drugs taken in combination to reduce its on blood pressure was significantly weaker than and nitrate drugs with clothes. Além disso, avanafil inhibition of phosphodiesterase 6 is very weak, a supressão de perturbação visual relevante pode a enzima fosfodiesterase 5 inibidor de induzido e outro.
Outras drogas similares são , Tadalafil e vardenafil. A vantagem do avanafil é que ele tem muito rápido início de ação em comparação com outros inibidores da PDE5. É absorvido rapidamente, atingindo uma concentração máxima em sobre 30-45 minutos. About two-thirds of the participants were able to engage in sexual activity within 15 minutos.
Avanafil Dose para a disfunção erétil:
Dose inicial: 100 mg orally as needed approximately 30 minutos antes da atividade sexual.
Dose de manutenção: 50 Para 200 mg por via oral conforme necessário 30 minutos antes da atividade sexual.
Dose máxima: 200 mg por via oral uma vez por dia
-The lowest dose that provides benefit should be taken.
-Sexual stimulation is needed for a response to treatment.
-Uso: Tratamento da disfunção erétil