O que é IGF-1 LR3? O que é IGF-1 Des?

IGF-1 (Fator de crescimento semelhante à insulina 1) é um hormônio endócrino que é produzido no fígado. A produção de IGF-1 é aumentada na presença de hormônio do crescimento.

Representa o fator de crescimento semelhante à insulina IGF. Fator de crescimento semelhante à insulina 1 (IGF-1) é um hormônio proteico de polipeptídeo de estrutura molecular semelhante à insulina . It plays an important role in childhood growth and continues to have effects in adults. It is a natural substance that is produced in the human body and is at its highest natural levels during puberty. (Editado por Hongxi Pharm)

During puberty IGF is the most responsible for the natural muscle growth that occurs during these few years. There are many different things that IGF does in the human body. Among the effects the most positive are increased amino acid transport to cells, increased glucose transport, increased protein synthesis, decreased protein degradation, and increased RNA synthesis.

IGF-1 LR3 Details:

IGF-1 Benefits:

Why is this IGF-1 important for a bodybuilder or athlete? Let’s take a look at the list:

• Helps regulate fat for use as energy, resulting in fat loss.
• Contributes to anti aging. As we get older, IGF-1 production slows down and this results in cell reduction. Low levels of IGF-1 are linked to heart failure, lower brain cell regulation and neuron function. Not to mention muscle tissue breakdown.
• Helps to increase nutrient shuttling (síntese de proteínas).
• Aumenta funções regenerativas de tecidos nervosos.
• Boosts the ability to cause hyperplasia in muscle cells resulting in fuller muscle tissue.

IGF-1 LR3 Specification:

IGF-1 LR3 and IGF-1 DES:

IGF-1 variants are split into two groups: IGF-1 LR3 and DES IGF-1 (usually presented as IGF-1 DES). Base IGF-1 has a very short half life (sobre 10-20 minutos); como resultado, it is quickly destroyed by the body. This is why IGF-1 was modified to make the amino acid analog IGF-1 LR3 (Long). The other variant of IGF-1 called DES IGF-1 is a truncated version that is 10X more potent than IGF-1. Both variants are similar to its root but have different actions, allowing them to function in a specific ways.

IGF-1 LR3

Long arginine 3-IGF-1, abbreviated as IGF-1 LR3 ou LR3-IGF-1, is a synthetic protein and lengthened analogue ofhuman insulin-like growth factor 1 (IGF-1). IGF-1 LR3 has a half-life of about 20-30 hours and is much more potent than base IGF-1. Since its half-life is about a day, the IGF-1 LR3 will circulate the body, for around 24 horas, binding to receptors and activating cell communication that improves muscle growth and fat loss.

LR3 prevents glucose from entering into cells, que, por sua vez, forces the body to burn fat and not sucrose. Além disso, its long half-life is desirable for another reason; site injections aren’t necessary, as IGF-1 LR3 will cycle the body binding to all muscle cells for about a day.

Long R3 IGF-1 is signifacantly more potent than IGF-1. The enhanced potency is due to the decreased binding of Long R3 IGF-1 to all known IGF binding proteins. These binding proteins normally inhibit the biological actions of IGF’s.

The amino acid sequence of IGF-1 LR3 is MFPAMPLSSL FVNGPRTLCG AELVDALQFV CGDRGFYFNK PTGYGSSSRR APQTGIVDEC CFRSCDLRRL EMYCAPLKPA KSA.

IGF-1 DES

DES IGF-1 is the shorter version of the IGF-1 chain. It is five (5) times more powerful than IGF-LR3 and ten (10) times more powerful than regular base IGF-1. The half-life for DES is about 20-30 minutos, which means this is a very delicate chain. Por conseguinte, administration should only be done at the site where you want to see muscle growth. DES has the ability to stimulate muscle hyperplasia better than LR3. Em termos simples, it’s best used for site injections, rather than overall growth.

des(1-3)IGF-1 lacks the first three amino acids at the N-terminus of IGF-1 (for a total of 67 os aminoácidos, relative to the 70 of IGF-1). As a result of this difference, it has considerably reduced binding to the insulin-like growth factor-binding proteins (IGFBPs) and enhanced potency relative to IGF-1.

The amino acid sequence of des(1-3)IGF-1 is TLCGAELVDA LQFVCGDRGF YFNKPTGYGS SSRRAPQTGI VDECCFRSCD LRRLEMYCAP LKPAKSA.

Além disso, DES is known to bind to receptors that have been deformed by lactic acid, which is often present during workouts. This allows the DES to attach itself to a mutated receptor and signal tissue growth during training. DES can be used longer and more frequently than LR3.

Quick Guide:
1. Swab the top of your sterile vial with alcohol prep pad (70% isopropyl alcohol)
2. Mix 7.5mL distilled water with 1.0mL vinegar
3. Add Whatman syringe filter
4. Add sterile ~20ga. needle to end of Whatman filter
5. Inject the 8.5mL of solution into the sterile vial
6. You now have sterile 0.6% ácido acético

Reconstituição de IGF-1 de LR3:

Reconstituição é simplesmente a adição da 0.6% AA para seu IGF-1 liofilizado.
Assunção: 1mg/mL de IGF-1/AA (1mg de IGF-1 será combinado com 1mL de AA; 1mg de IGF-1 é igual a 1, 000mcg) (Editado por Hongxi Pharm)

1. Limpe a parte superior do seu IGF-1 frasco com uma almofada da preparação do álcool estéril
   2. Limpe a parte superior do seu 0.6% AA frasco com uma almofada da preparação do álcool estéril
   3. Usando qualquer vários volumes de seringa de insulina (exemplo de: 2 x 0.5cc) ou uma simples seringa grande, obter 1,0 mL de 0.6% AA.
   4. No frasco de IGF-1, inserir um estéril ~ 20 ga. agulha para atuar como um respiradouro
   5. Injetar 1,0 mL de AA muito lentamente e driblo isso do lado do frasco.
   um. Tenha muito cuidado com este peptídeo como é muito delicado!
   6. Retire a agulha & seringa e descarte
   7. Suavemente agitar o frasco ou rolar entre as mãos.
   um. Mais uma vez, muito cuidado aqui
   8. Agora você tem 1mg/mL de IGF-1
   um. Este é o mesmo que: 1,000mcg/mL

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